This work presents the fourth installment in a systematic series of acyl tryptamine conjugates designed as multi‑target prodrug candidates addressing neuroinflammation, metal dyshomeostasis, oxidative stress, cellular senescence, and serotonergic dysregulation. Building on our previous preprints in this series, we extend the structural space to additional heteroaromatic and natural product–derived acyl motifs, providing a focused library with fine‑tuned physicochemical and pharmacological properties. We report the synthesis, analytical characterization, and stability assessment of all conjugates, together with an updated discussion of their dual‑release concept, putative activation pathways, and relevance for neurodegenerative and neuropsychiatric disorders. This deposit provides an openly accessible, citable version of the manuscript and associated materials, facilitating reuse, comparison, and further development of this compound class.
Stanley Kisourin (Sat,) studied this question.