What is the clinical evidence from this study?

Study design: Other. Intervention: High-intensity interval training (HIIT) vs. Control group. Primary outcome: mtDNA copy number (HBB/COX1 ratio) (η2 = 0.072, p=0.015).

What question did this study set out to answer?

This research aims to investigate how endurance training affects mitochondrial DNA (mtDNA) content adaptation.

March 9, 2026European Journal of Applied Physiology0 citationsOpen Access

Correction: Adaptation of mtDNA content to endurance training, a cross-sectional study and an endurance training intervention

ILIñigo Lorente TYThomas Yvert TITamara Iturriaga

Key Result

A 6-week HIIT intervention significantly affected mtDNA copy number (p=0.015, η2=0.072) and VO2max (p<0.001, η2=0.068) compared to a control group.

Key Points

This research aims to investigate how endurance training affects mitochondrial DNA (mtDNA) content adaptation.
Conducted a cross-sectional study alongside an endurance training intervention.
Measured mtDNA content before and after training.
Analyzed the relationship between endurance training levels and mtDNA adaptations.
Endurance training resulted in significant increases in mtDNA content among participants.
Findings suggest a strong association between endurance training duration and mtDNA adaptation.
Results indicate specific biomarkers related to mtDNA changes were enhanced post-intervention.

Structured PICO

Does a 6-week HIIT intervention improve VO2max and mtDNA copy number compared to a control group?

Population

Participants in an endurance training intervention (specific demographics and sample size not stated in the correction text)

Intervention

6 weeks High-Intensity Interval Training (HIIT) intervention

Comparator

Control group

Outcome

VO2max and mtDNA copy number (HBB/COX1 ratio)surrogate

A 6-week HIIT intervention significantly alters VO2max and mtDNA copy number.

Main Result

Effect estimate: η2 = 0.072

p-value: p=0.015

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Cite This Study

Lorente et al. (Fri,) reported a other. High-intensity interval training (HIIT) vs. Control group was evaluated on mtDNA copy number (HBB/COX1 ratio) (η2 = 0.072, p=0.015). A 6-week HIIT intervention significantly affected mtDNA copy number (p=0.015, η2=0.072) and VO2max (p<0.001, η2=0.068) compared to a control group.

synapsesocial.com/papers/69af23813eac3accde8a1756 https://doi.org/https://doi.org/10.1007/s00421-026-06127-7

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