Locomotive syndrome stage 3 was independently associated with a 3.51-fold higher odds of elevated NT-proBNP (≥125 pg/mL) compared to individuals without locomotive syndrome.
Cross-Sectional (n=8,593)
No
Does locomotive syndrome severity correlate with elevated NT-proBNP in asymptomatic adults undergoing routine health screening?
Locomotive syndrome severity is independently associated with elevated NT-proBNP in asymptomatic adults, suggesting physical function decline may reflect early subclinical myocardial stress.
Odds Ratio: 3.51 (95% CI 2.02–6.12)
p-value: p=<0.001
Background: Locomotive syndrome (LS), an early predictor of physical frailty, is frequently evaluated during health screenings in Japan. However, its relationship with early cardiac dysfunction remains unclear. We investigated the association between LS severity and N-terminal pro B-type natriuretic peptide (NT-proBNP) concentration, a myocardial stress biomarker, in a general health screening population.
Mizuno et al. (Fri,) conducted a cross-sectional in General health screening population (n=8,593). Locomotive syndrome stage 3 vs. Non-locomotive syndrome was evaluated on Elevated NT-proBNP (≥125 pg/mL) (OR 3.51, 95% CI 2.02-6.12, p=<0.001). Locomotive syndrome stage 3 was independently associated with a 3.51-fold higher odds of elevated NT-proBNP (≥125 pg/mL) compared to individuals without locomotive syndrome.