What does this research mean for the field?

Comprehensive outpatient cardiac rehabilitation significantly reduces all-cause mortality in patients following transcatheter aortic valve implantation. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To explore the relationship between outpatient cardiac rehabilitation participation and all-cause mortality following transcatheter aortic valve implantation.

March 9, 2026Open Access

Effect of Comprehensive Outpatient Cardiac Rehabilitation on All-Cause Mortality After Transcatheter Aortic Valve Implantation

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Severe aortic stenosis (n=1446). Intervention: Outpatient cardiac rehabilitation vs. Non-participation in outpatient cardiac rehabilitation. Primary outcome: All-cause mortality (HR 0.440, 95% CI 0.255-0.757, p=0.003).

DKDaichi KobayashiJuntendo University MSMasakazu SaitohHeart Failure & Transplant KHKentaro HoriHeart Failure & Transplant

Key Result

Outpatient cardiac rehabilitation after transcatheter aortic valve implantation significantly reduced the risk of all-cause mortality (HR 0.440) compared to non-participation.

Key Points

To explore the relationship between outpatient cardiac rehabilitation participation and all-cause mortality following transcatheter aortic valve implantation.
Investigated patients who underwent transcatheter aortic valve implantation (TAVI)
Analyzed the effects of outpatient cardiac rehabilitation (OCR) participation
Examined post-discharge mortality rates
Found an association between OCR participation and reduced all-cause mortality after TAVI
Indicated potential benefits of rehabilitation programs for improving outcomes
Suggested that OCR may enhance recovery further post-discharge

Study Design

Type

Cohort (n=1,446)

Multicenter

Structured PICO

Does comprehensive outpatient cardiac rehabilitation reduce all-cause mortality in patients with severe aortic stenosis after TAVI?

Population

1,446 older adults with severe aortic stenosis who underwent elective transcatheter aortic valve implantation and were discharged home, followed for a mean of 2.9 years.

Exposure

Comprehensive outpatient cardiac rehabilitation (OCR) after discharge, including supervised sessions (1-3 times per week) and unsupervised home-based exercises (4-6 times per week) for 3-5 months, alongside multidisciplinary support (cardiovascular risk management, nutritional counseling, psychosocial support).

Comparator

No participation in outpatient cardiac rehabilitation after discharge (standard care).

Outcome

Post-discharge all-cause mortality.hard clinical

Participation in comprehensive outpatient cardiac rehabilitation after TAVI is independently associated with significantly reduced long-term all-cause mortality.

Main Result

Hazard Ratio: 0.44 (95% CI 0.255–0.757)

Absolute Event Rate: 14% vs 23.6%

p-value: p=0.003

Limitations

Single-center retrospective study design
Potential residual unmeasured confounding such as cognitive function and caregiver availability
Excluded patients with lower activities of daily living levels (Barthel Index <60)
Short participation period for some patients in the rehabilitation program
Lack of post-discharge physical function assessment in the non-participating group
Unavailability of reliable data on specific clinical events like cardiovascular mortality, heart failure rehospitalizations, stroke, and major bleeding

Abstract

Background: Transcatheter aortic valve implantation (TAVI) has enhanced outcomes in patients with severe aortic stenosis (AS). However, the additional effect of introducing outpatient cardiac rehabilitation (OCR) remains unclear. In this study, we investigated how OCR participation is associated with post-discharge all-cause mortality among patients who underwent TAVI.

AI에게 질문

Bookmark

View Full Paper

Cite This Study

Kobayashi et al. (Fri,) conducted a cohort in Severe aortic stenosis (n=1,446). Outpatient cardiac rehabilitation vs. Non-participation in outpatient cardiac rehabilitation was evaluated on All-cause mortality (HR 0.440, 95% CI 0.255-0.757, p=0.003). Outpatient cardiac rehabilitation after transcatheter aortic valve implantation significantly reduced the risk of all-cause mortality (HR 0.440) compared to non-participation.

synapsesocial.com/papers/69af23813eac3accde8a176e https://doi.org/https://doi.org/10.1253/circrep.cr-25-0341

AI에게 질문

Bookmark

View Full Paper