Molecular biological effect of Rbm20 I538T knock-in mice on skeletal muscle

Key Points

• To investigate the molecular biological effects of Rbm20 I538T knock-in on skeletal muscle.
• Used Rbm20 I538T knock-in mice model.
• Analyzed gene expression and protein functions in skeletal muscle tissue.
• Conducted comparative assessments with wild-type mice.
• Significantly altered gene expression profiles in Rbm20 I538T vs. wild-type mice (p<0.01).
• Dysregulation of key proteins impacting muscle metabolism observed.
• Increased muscle fibrosis noted in Rbm20 I538T knock-in mice.