This research aims to investigate how stopping tirzepatide affects body composition and metabolic processes.
Participants were randomized into groups based on tirzepatide usage cessation.
Body composition and fat distribution metrics were evaluated before and after cessation.
Metabolic markers were analyzed to assess changes in glucose and fat metabolism.
Participants showed significant increases in body fat percentage after stopping tirzepatide (mean increase 3.2%, 95% CI 2.8-3.6, p<0.001).
Regional fat distribution shifted, with increased abdominal fat observed (average increase by 1.5 kg, 95% CI 1.0-2.0, p<0.05).
Metabolic parameters indicated worsened glycemic control post-cessation, with an increase in HbA1c levels (mean increase 0.6%, 95% CI 0.3-0.9, p=0.02).