Psychological Impacts on Peyronie’s Disease and Its Treatments: A Narrative Review of Current Evidence

Peyronie’s disease (PD) is a prevalent genital condition characterized by fibrosis of the tunica albuginea in men. The resultant penile deformities, pain, shortening, and erectile dysfunction render patients with PD susceptible to psychiatric disorders. The current study aims to summarize the psychological impacts on PD and its treatments via a narrative review. Seventeen clinical studies were finally included for analysis. According to these eligible studies, the prevalence of depression and anxiety ranged from 12% to 62% and 7% to 75%, respectively. Other types of psychiatric disorders in PD patients included distress, mood disorder, self‐injurious, isolation, anger, loss of confidence, frustration, and loss of self‐esteem. Except for intralesional collagenase, some specific treatments, that is, dermal graft repair, inflatable penile prosthesis, antidepressants, and psychotherapy could improve PD‐associated psychological disorders. Clinicians should provide a complete perspective on psychological aspects in counseling PD patients as well as their partner. This review summarized recent evidence on the psychological impacts of PD and its various treatments. A meta‐analysis was not performed, which represents a limitation of this study. Nonetheless, the present review underscores the substantial psychological burdens experienced by individuals with PD.