Synthesis of Dibenzo‐1,2,3‐Triazole Fused 14‐Membered Oxa‐Ketone Macrocycles via Azide‐Alkyne Cycloaddition

Key Points

• The study aims to synthesize dibenzo-1,2,3-triazole fused 14-membered oxa-ketone macrocycles.
• Used cross-aldol precursors for synthesis.
• Employed Cu(I)/Ag(I) catalysis for azide-alkyne cycloaddition.
• Synthesized a series of macrocycles with varying yields.
• Successfully synthesized dibenzo-1,2,3-triazole fused macrocycles in yields of 61% to 92%.
• Achieved the synthesis for the first time.
• Demonstrated effective use of azide-alkyne cycloaddition.