What does this research mean for the field?

This clinical practice guideline supports safer, sex-sensitive prescribing of antipsychotic medications for females experiencing a first episode of psychosis, potentially improving treatment acceptability and adherence. Novelty: ClaimNovelty.SYNTHESIS. Consensus alignment: ConsensusAlignment.ESTABLISHES_NEW_DIRECTION.

What question did this study set out to answer?

To develop a clinical practice guideline for selecting antipsychotic medications for females experiencing their first episode of psychosis.

March 10, 2026Schizophrenia Bulletin0 citationsOpen Access

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Clinical Practice Guideline on the Choice of First Antipsychotic Medicine for Females Experiencing a First-Episode of Psychosis

CHCaroline Hynes DKDolores Keating ACAoife Carolan

Key Points

To develop a clinical practice guideline for selecting antipsychotic medications for females experiencing their first episode of psychosis.
Conducted a review of existing literature on antipsychotic choices for females
Emphasized patient outcomes and lived experiences in the guideline
Developed recommendations for safe, sex-sensitive prescribing practices
Introduced the first guideline tailored for females with first-episode psychosis
Highlighting the importance of treatment acceptability and adherence
Improved equity in psychosis care for females through targeted recommendations

Abstract

This is the first CPG addressing antipsychotic choice for females with FEP. By prioritizing critically important patient outcomes and lived experience, the guideline supports safer, sex-sensitive prescribing for females that may improve treatment acceptability, adherence, and equity in psychosis care.

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Cite This Study

Hynes et al. (Wed,) studied this question.

synapsesocial.com/papers/69af955970916d39fea4cc4f https://doi.org/https://doi.org/10.1093/schbul/sbag023

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