Halogen bonding is an attractive tool in organic chemistry; however, chiral catalysts bearing halogen bond donor functionalities remain underexplored. Herein, we investigate the development and catalytic applications of binaphthyl‐based chiral bromonium and iodonium salts. While previously reported catalysts have been successfully applied in several transformations, their utilization in the construction of vicinal chiral tetrasubstituted carbon stereogenic centers remains challenging. The introduction of bulky substituents into the core structure is an effective methodology for designing chiral catalysts. In this study, chiral halonium salts bearing bulky silyl ether substituents were synthesized and employed as halogen bonding‐driven catalysts for the challenging formation of vicinal chiral tetrasubstituted stereogenic centers, affording the corresponding products in high yields and up to 92% ee.
Yoshida et al. (Fri,) studied this question.