Mechanochemical Base-Catalyzed Isomerization and Deuteration of Allylbenzenes

Key Points

• The aim is to explore mechanochemical methods for the isomerization and deuteration of allylbenzenes to improve pharmacokinetic properties.
• Utilized mechanochemical techniques for base-catalyzed reactions
• Focused on allylbenzenes to assess effectiveness
• Analyzed the impact on pharmacokinetic and metabolic stability
• Deuteration significantly improved pharmacokinetic properties.
• Enhanced metabolic stability was observed through the deuterium kinetic isotope effect.