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Plasma-activated hydrogel promotes postoperative colonic anastomotic leak healing | Synapse

March 10, 2026Open Access

Plasma-activated hydrogel promotes postoperative colonic anastomotic leak healing

Key Points

To evaluate the efficacy of a plasma-activated hydrogel in healing colonic anastomotic leaks.
Used a rat model of colonic anastomosis.
Administered plasma-activated hydrogel at the surgical site.
Assessed healing outcomes based on anastomotic leak rates.
Hydrogel application showed reduced rates of anastomotic leaks.
Improved healing observed compared to controls.
Potential for clinical application in gastrointestinal surgeries.

Abstract

Hyd@CAP represents an emerging therapeutic strategy with potential applications in the management of AL following gastrointestinal surgery. Its efficacy has been preliminarily validated in a rat model of CAL, suggesting potential for early-phase clinical translation and possible extension to anastomotic repair throughout the entire gastrointestinal tract.

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Cite This Study

Han et al. (Sun,) studied this question.

synapsesocial.com/papers/69af95cf70916d39fea4dc2b https://doi.org/https://doi.org/10.1016/j.jare.2026.02.056