Exercise inhibits proliferation and induces apoptosis of lung adenocarcinoma cells via the POU2F2-SPOCD1-PI3K/AKT signaling axis

Key Points

• The research focuses on how exercise affects lung adenocarcinoma cell functions, specifically inhibition of growth and induction of cell death.
• Examined the impact of exercise on lung adenocarcinoma cells.
• Analyzed the role of POU2F2 and SPOCD1 in cell proliferation and apoptosis.
• Evaluated PI3K/AKT signaling pathway activation in relation to exercise.
• Exercise significantly inhibits the proliferation of lung adenocarcinoma cells.
• Exercise induces apoptosis in these cancer cells.
• Downregulation of POU2F2 leads to decreased activation of the PI3K/AKT pathway.