Introduction: Alzheimer's disease (AD) is a progressive neurodegenerative disorder influenced by a complex interplay of genetic, environmental, and metabolic factors.Emerging evidence suggests that the gut microbiota significantly contributes to AD pathogenesis via the gut-brain axis, a bidirectional communication network linking gastrointestinal health with brain function.High-sugar diet profoundly alters the composition and functionality of the gut microbiota, promoting dysbiosis and the overgrowth of opportunistic bacterial species, which results in increased production of microbial fermentation products, impaired intestinal integrity, and induced systemic inflammation, and endothelial dysfunction. Aim of the Study:This review aims to elucidate the mechanistic links between diet-induced dysbiosis and the progression of AD, with a focus on the roles of specific microbial metabolites, immune modulation, and metabolic disruptions in exacerbating neurodegenerative processes. Materials and Method:A comprehensive review of the literature was performed, integrating insights from 148 peer-reviewed publications.The review integrated evidence on the impact of high-sugar diets on gut microbiota, the resultant alterations in microbial fermentation products, and their subsequent effects on the gut-brain axis, neuroinflammation, amyloid pathology, and cognitive decline in AD. Conclusion:The study demonstrates that excessive sugar intake disrupts gut microbiota balance, triggering systemic inflammation through the gut-brain axis and driving neurodegeneration.These findings highlight the potential of gut-targeted interventions to mitigate AD risk and progression.Further research is essential to validate these mechanisms in larger, diverse populations and to elucidate the specific molecular pathways involved, ultimately guiding the development of targeted therapeutic strategies for AD.
Ibeanu et al. (Sun,) studied this question.