Single-Metal-Doped Nanoplatforms In their Research Article (10.1002/adfm.202520463), Malcolm Xing, Shiming Yang, and co-workers present manganese-doped metal–organic frameworks that induce ferroptosis-mediated release of endogenous mitochondrial DNA, thereby synergistically activating the manganese-specific cGAS-STING signaling pathway to promote dendritic cell maturation and remodel the immunosuppressive tumor microenvironment in liver cancer.
Zhang et al. (Sun,) studied this question.