Hand-dominant joint involvement pattern associates with favourable, and polyarthritis with unfavourable, treatment response to both csDMARDs and bDMARDs in early rheumatoid arthritis: a combined analysis of NORD-STAR and BeSt trials | Synapse
March 12, 2026Open Access
Hand-dominant joint involvement pattern associates with favourable, and polyarthritis with unfavourable, treatment response to both csDMARDs and bDMARDs in early rheumatoid arthritis: a combined analysis of NORD-STAR and BeSt trials
Key Points
Assess how joint involvement patterns correlate with treatment responses to csDMARDs and bDMARDs in early rheumatoid arthritis.
Combined analysis of NORD-STAR and BeSt trials
Evaluated treatment responses to conventional and biological disease-modifying antirheumatic drugs (csDMARDs and bDMARDs)
Compared outcomes based on hand-dominant joint involvement (JIP-Hand) versus polyarthritis (JIP-Poly).
JIP-Hand showed the greatest improvement in disease activity with both csDMARDs and bDMARDs.
JIP-Poly exhibited the least improvement in disease activity with both treatment types.
Abstract
In early RA, csDMARD and bDMARD treatments resulted in the greatest improvement in disease activity in JIP-Hand and the least improvement in JIP-Poly.