Preclinical advances and mechanistic insights of CAR-T therapy for acute myeloid leukemia: from target iteration to microenvironment regulation

Key Points

• This research focuses on improving CAR-T therapy for acute myeloid leukemia (AML) through technological advancements and combination strategies.
• Exploration of multidimensional technological innovations.
• Evaluation of combination therapy strategies.
• Assessment of CAR-T therapy adaptations for AML.
• Technological innovations demonstrated potential to enhance CAR-T therapy efficacy.
• Combination therapies showed promise in overcoming AML-specific treatment barriers.
• Improved survival outcomes projected for patients with relapsed/refractory AML.