Food-derived bioactive compounds have long been studied for their safety, cost-effectiveness, and potential industrial applicability. In this study, Sangyod rice extract from a traditional Thai rice variety was investigated using cell-based models to evaluate its antioxidant capacity and its effects on cellular oxidative status, lipid accumulation, and lipid metabolism–related signaling pathways. The extract was further assessed for its influence on inflammatory response, apoptosis-related markers, and proteins associated with lipid metabolism. The results demonstrated that treatment with the extract significantly reduced reactive oxygen species production and lipid accumulation in oleic acid–induced HepG2 cells. Furthermore, Sangyod rice extract modulated key regulators of lipid metabolism, including sterol regulatory element binding protein 1c (SREBP-1c), acetyl–CoA carboxylase (ACC), carnitine palmitoyltransferase I (CPT-1), fatty acid synthase (FASN), microsomal triglyceride transfer protein (MTTP), peroxisome proliferator-activated receptor (PPAR) γ coactivator 1α (PGC-1α), and PPARα. In addition, the extract influenced Akt and mitogen-activated protein kinase (MAPK) signaling pathways. These findings suggest that Sangyod rice extract is a promising source of bioactive compounds with measurable functional activity in vitro and may have potential for further development in functional food and nutraceutical applications. • Sangyod rice extract was associated with lower ROS and lipid accumulation. • Sangyod rice extract modulated SREBP-1c, PGC-1α, and PPARα expression. • Sangyod rice extract altered lipid metabolism–related enzyme expression. • Sangyod rice extract modulated Akt and MAPK pathway activation.
Moolsup et al. (Sun,) studied this question.
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