Activation Syndrome in Patients Diagnosed With Major Depressive Disorder for the First Time

Key Points

• This research aims to investigate the relationship between activation syndrome and symptoms in first-episode major depressive disorder.
• Examined patients with first-episode major depressive disorder
• Evaluated past hypomania symptoms
• Analyzed the presence of atypical depression
• Increased risk of activation syndrome observed in patients with past hypomania
• Atypical depression shows correlation with activation syndrome
• Close monitoring is recommended due to implications for bipolarity and suicidality