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This research evaluates the agreement between single and multiple ROI strategies for measuring hepatic T1 and ECV in specific patient groups.

March 12, 2026Abdominal Radiology0 citationsOpen Access

Agreement between single and multiple ROI strategies for hepatic T1 and ECV mapping in tetralogy of Fallot and Fontan circulation

AIAdriana MacIntyre Innocenzi FFFernanda Padrão Fernandes JSJosé Carlos P. Secco

Key Points

This research evaluates the agreement between single and multiple ROI strategies for measuring hepatic T1 and ECV in specific patient groups.
Measurements taken using single-wide ROI and multiple-small ROI strategies.
Participants included individuals with repaired Tetralogy of Fallot and Fontan circulation.
Statistical analyses included ICC and survival-agreement analyses to assess agreement between methods.
Excellent agreement found in hepatic native T1 and ECV measurements between ROI strategies in repaired Tetralogy of Fallot.
Good concordance noted in Fontan patients, highlighting the feasibility of both strategies for measuring hepatic parameters.
Greater hepatic heterogeneity in Fontan patients requires caution when interpreting results from different ROI approaches.

Abstract

Hepatic native T1 and ECV measurements showed excellent agreement between single-wide and multiple-small ROI strategies in repaired TOF, supporting interchangeable use for longitudinal follow-up. In Fontan patients, concordance between methods was also good, as demonstrated by both ICC and survival-agreement analyses, indicating that either strategy remains feasible; nonetheless, the greater hepatic heterogeneity in this population warrants some caution when comparing measurements obtained with different ROI approaches.

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