What does this research mean for the field?

Longitudinal trajectories of metabolic risk clusters are associated with differential risks of CKD progression to ESKD and death in patients with chronic kidney disease. Novelty: ClaimNovelty.CONFIRMATORY. Consensus alignment: ConsensusAlignment.SUPPORTS_CONSENSUS.

What question did this study set out to answer?

To investigate how different trajectories of metabolic risk clusters affect the progression of chronic kidney disease (CKD) and associated outcomes.

March 12, 2026BMJ Open0 citationsOpen Access

Trajectories of metabolic risk clusters and adverse outcomes in patients with chronic kidney disease: a prospective cohort study in Taiwan

WLWei-Cheng Lo MWMei-Yi Wu YCYi-Hsuan Roger Chen

Key Points

To investigate how different trajectories of metabolic risk clusters affect the progression of chronic kidney disease (CKD) and associated outcomes.
Longitudinal analysis of metabolic risk clusters in patients with chronic kidney disease
Assessment of CKD progression to end-stage kidney disease (ESKD)
Monitoring mortality rates related to CKD
Identified distinct trajectories of metabolic risk clusters over time
Certain clusters showed significantly higher risks of CKD progression to ESKD
Variations in metabolic risk profiles were linked to differential mortality rates

Abstract

Longitudinal trajectories of metabolic risk cluster are associated with differential risks of CKD progression to ESKD and death. Our findings provide valuable insights into the monitoring of metabolic risk profiles over time in patients with CKD.

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