What question did this study set out to answer?

The primary aim is to discover and synthesize novel phenylindole-bisamide derivatives that effectively inhibit P-glycoprotein.

March 12, 2026RSC Medicinal Chemistry0 citations

Rational discovery of novel phenylindole-bisamide derivatives as potent P-glycoprotein inhibitor for Cancer Multidrug Resistance

View Full Paper

ZYZhikun Yang JHJiajia Han YYYanhong Yang

Key Points

The primary aim is to discover and synthesize novel phenylindole-bisamide derivatives that effectively inhibit P-glycoprotein.
Designed and synthesized a series of novel derivatives
Tested the inhibitory effects on P-glycoprotein
Evaluated the potential for overcoming multidrug resistance in cancer
Identified several derivatives with potent P-gp inhibition
Demonstrated significant effectiveness in overcoming cancer multidrug resistance
Showed improved drug retention in cancer cells with high P-glycoprotein expression

Abstract

Overcoming multidrug resistance (MDR) remains a major challenge in cancer chemotherapy, largely mediated by the efflux pump P-glycoprotein (P-gp). To address this, we designed and synthesized a series of novel...

AI से पूछें

Bookmark

View Full Paper

Cite This Study

Yang et al. (Thu,) studied this question.

synapsesocial.com/papers/69b2580996eeacc4fcec74c6 https://doi.org/https://doi.org/10.1039/d6md00030d

AI से पूछें

Bookmark

View Full Paper