Facile generation and reaction of densely trifluoromethylated alkyl radicals by dual photoredox and acid catalysis

Key Points

• This research aims to develop a straightforward method for generating densely trifluoromethylated alkyl radicals.
• Utilized dual photoredox and acid catalysis for radical generation.
• Employs readily available fluorinated alkyl benzoates as precursors.
• Focused on the generation of the nonafluoro-tertbutyl radical.
• Successfully generated densely trifluoromethylated alkyl radicals.
• Demonstrated efficacy of the method with various fluorinated alkyl benzoates.
• Highlighted applications in synthetic chemistry.