Abstract Iron overload (IO) is a pathological condition characterized by excessive iron accumulation, leading to systemic functional impairment. It frequently occurs in patients with congenital or acquired anemia, such as aplastic anemia, who require long‐term transfusions. Iron chelation therapy (ICT) is the standard approach for managing transfusion‐related IO. However, the currently available iron chelators are limited by their toxicity and administration challenges. Hetrombopag (HPAG), an oral small‐molecule non‐peptide thrombopoietin receptor agonist (TPO‐RA), has been approved for the treatment of immune thrombocytopenia and aplastic anemia. HPAG contains an iron‐scavenging moiety that functions independently of its TPO‐RA activity; however, its role in ICT has not been clearly defined. In this study, we conducted a longitudinal evaluation of iron burden in clinical cohorts of patients with severe aplastic anemia treated with immunosuppressive therapy alone or in combination with HPAG therapy. Complementary preclinical models mimicking transfusion‐induced IO have been used to elucidate the therapeutic potential and underlying mechanisms. Our findings identified HPAG as a potent iron‐chelating agent with both prophylactic and therapeutic efficacy against systemic IO. Mechanistically, HPAG functions as a potential ferroptosis inhibitor by significantly reducing toxic iron accumulation, suppressing iron‐induced lipid peroxidation at the cellular level, and alleviating systemic complications. These findings advance our understanding of transfusional IO and support the idea that targeting ferroptosis is a novel therapeutic strategy for systemic IO.
Zhao et al. (Sun,) studied this question.