What does this research mean for the field?

Trifolium pratense L. extract improves neuroprotection against propofol-induced ischemic brain injury in rats by regulating GRP78/ATF-6 and Bax-Bcl2/p53 signaling pathways. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

The objective is to investigate how Trifolium pratense extract affects neuroprotection and the underlying molecular pathways in ischemic brain injury.

March 12, 2026Open Access

Trifolium pratense L. Extract Improves Propofol-Induced Neuroprotection via Regulating GRP78/ ATF-6 and Bax-bcl2/p53 Signaling in Ischemic Brain Injury in Rats

Key Points

The objective is to investigate how Trifolium pratense extract affects neuroprotection and the underlying molecular pathways in ischemic brain injury.
Administered Trifolium pratense extract to rats with induced ischemic brain injury
Measured the expression of GRP78, ATF-6, Bax, Bcl2, and p53
Evaluated neuroprotective effects using propofol as a treatment approach
Trifolium pratense extract significantly improved neuroprotection in rats
Regulated key signaling molecules GRP78/ATF-6 and Bax/Bcl2/p53
Showed enhanced brain function recovery post-ischemic injury

Abstract

El Extracto de Trifolium pratense L. Mejora la Neuroproteccin

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Cite This Study

Li et al. (Mon,) studied this question.

synapsesocial.com/papers/69b2581996eeacc4fcec76e1 https://doi.org/https://doi.org/10.4067/s0717-95022025000601909

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