What question did this study set out to answer?

This research aims to investigate the gut resistome of the Wayampi and compare it with industrialized populations.

March 12, 2026Open Access

The antimicrobial gut resistome of the Wayampi reveals a shared background of antibiotic and metal resistance genes with industrialized populations, underscoring the “robust-yet-fragile” architecture of human gut microbiomes

Key Points

This research aims to investigate the gut resistome of the Wayampi and compare it with industrialized populations.
Analyzed the resistome composition of Wayampi gut microbiomes
Compared acquired antibiotic and metal resistance genes (ARGs and MRGs) with industrialized populations
Assessed the structural characteristics of the resistome using scale-free network analysis
Identified a diverse resistome in the Wayampi, indicating a less perturbed microbiome
Noted a shared background of 'core' and 'shell' acquired ARGs and MRGs with industrialized groups
Observed a patchy yet resilient distribution of resistance genes, suggesting an evolutionarily shaped microbial landscape

Abstract

The diverse and balanced Wayampi resistome reflects a less perturbed microbiome compared to industrialized populations, and reveals a background of "core" and "shell" acquired ARGs and MRGs, consistent with the "robust-yet-fragile" architecture of scale-free networks. The patchy yet resilient gene distribution suggests varying levels of conserved gene sharing highways among populations, likely shaped by long-term microbial-human evolution, and supports a broader view on acquired antimicrobial resistance. Video Abstract.

AIに質問

Bookmark

View Full Paper