Mechanistic Insights Into Wnt/β‐Catenin Pathway Modulation in Chronic Low Back Pain and Anxiety‐ and Depression‐Related Behaviour in Male Sprague Dawley Rats | Synapse
March 12, 2026
Mechanistic Insights Into Wnt/β‐Catenin Pathway Modulation in Chronic Low Back Pain and Anxiety‐ and Depression‐Related Behaviour in Male Sprague Dawley Rats
Key Points
This research aims to explore how modulating the Wnt/beta-catenin pathway affects hyperalgesia and anxiety-related behaviours associated with chronic low back pain.
Examined the Wnt/beta-catenin signalling pathway in a rat model.
Induced chronic nonspecific low back pain in male Sprague Dawley rats.
Conducted behavioral assessments to measure anxiety-like behaviours and pain responses.
Modulation of the Wnt/beta-catenin pathway influenced levels of hyperalgesia in rats.
Altered behaviour suggested changes in anxiety-like responses related to chronic pain.
Abstract
Modulating the spinal Wnt/β-catenin signalling pathway may be pivotal for elucidating the mechanisms underlying hyperalgesia and anxiety-like behaviour in chronic nonspecific low back pain (CNLBP).