Our findings demonstrate that exercise-induced adaptations in metabolism distinctly shape the human serum metabolome and influence the metabolic response to exercise. These insights are relevant for diseases driven by dysfunctional metabolism, such as impaired fat oxidation and dysregulated glycolysis (e.g., diabetes, dementia) and muscle wasting (e.g., sarcopenia), where our specialized populations may serve as useful models.
Schranner et al. (Mon,) studied this question.