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March 12, 2026Open Access

Skin hypersensitivity in chronic cough patients: symptom profiles and psychosomatic correlates

TZTongyangzi ZhangTongji Hospital HWHeng WuTongji University HBHaodong BaiTongji Hospital

Key Points

This research aims to explore the occurrence of skin hypersensitivity in chronic cough patients and its relationship with psychological factors.
Identified skin hypersensitivity in chronic cough patients, specifically those with refractory-uncontrolled chronic cough (RU-CC).
Correlated findings with levels of neural hypersensitivity and psychological distress.
Recommended early recognition and treatment interventions with neuromodulators.
Skin hypersensitivity was prevalent in a significant subset of chronic cough patients.
High levels of neural hypersensitivity and psychological distress were associated with the condition.
Early introduction of neuromodulators may enhance overall patient outcomes.

Abstract

SSS was identified in a clinically relevant subset of CC patients (especially those with RU-CC) and correlated with neural hypersensitivity and psychological distress. Early recognition of SSS in patients with CC and the early introduction of neuromodulators may offer greater therapeutic benefits and improve patient outcomes.

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