Immunogenetic Interplay of IL-6 and IL-6R Genes Variants and Circulating IL-6 Levels in Toxoplasma gondii-infected Women with Recurrent Pregnancy Loss.

Key Points

• The study aims to explore the association between IL-6 and IL-6R gene variants and recurrent pregnancy loss (RPL) in women infected with Toxoplasma gondii.
• Assessment of IL-6 -174G/C and -597G/A polymorphisms in women
• Evaluation of IL-6R A/C gene variants
• Measurement of circulating IL-6 levels in the participants
• IL-6 gene variants were significantly associated with an increased risk of RPL in the studied population.
• Altered circulating IL-6 levels were linked to specific gene polymorphisms, impacting bioavailability.
• The presence of IL-6R variants correlated with heightened IL-6 levels in infected individuals.