G9a inhibition reduces stress‐potentiated alcohol drinking in both male and female mice: Implications for safe and effective pharmacological therapeutics for alcohol use disorder

Key Points

• This research aims to explore the potential of G9a inhibitors as therapeutics for reducing alcohol consumption associated with stress in alcohol use disorder.
• Used male and female mice for the experimental study design.
• Administered G9a inhibitors to evaluate effects on alcohol consumption.
• Measured stress-related drinking behaviors in response to pharmacological intervention.
• G9a inhibition significantly reduced alcohol intake during stress conditions.
• Findings suggest a potential therapeutic option for treating alcohol use disorder with fewer safety concerns.