The study investigates how IL-17A contributes to NETs formation during ischemic stroke and its potential as a therapeutic target.
Utilized a mouse model of ischemic stroke
Examined the role of IL-17A in facilitating NETs formation
Analyzed the PKCζ-ERK-ROS pathway's involvement in the process
Assessed PAD4 expression levels
IL-17A was found to significantly upregulate PAD4
Activation of the PKCζ-ERK-ROS pathway was confirmed
NETs formation was exacerbated in the presence of IL-17A
Targeting these pathways may reduce ischemic brain injury
Abstract
IL-17A promotes NETs formation by upregulating PAD4 through the PKCζ-ERK-ROS pathway, exacerbating ischemic brain injury. Targeting this axis may offer a novel therapeutic strategy for stroke.