Creutzfeldt–Jakob Disease: Spectrum of Symptoms, Clinical Progress and Diagnostics—Report of Five Cases

Creutzfeldt–Jakob disease (CJD) is a rare, fatal prion disease of the central nervous system that develops due to the conversion of the normal cellular protein PrPc to the abnormal PrPSc molecule. The first clinical cases were described in the 1920s. The aim of this paper is to present the clinical progress of the disease and the diagnostic process, including some of the most common diagnostic traps. The paper highlights a range of symptoms that should serve as a potential warning signal for clinicians—not just neurologists—indicating the need to evaluate the patient more thoroughly.