What is the clinical evidence from this study?

Study design: Meta-Analysis. Population: Cryptogenic stroke (n=3740). Intervention: Device closure vs. Medical therapy (aspirin). Primary outcome: Recurrent stroke rate (HR 0.41, 95% CI 0.28-0.60, p=<0.001).

What question did this study set out to answer?

The aim is to explore the various underlying pathologies of ischemic stroke and assess how antithrombotic therapy can help prevent recurrence.

March 13, 2026Open Access

Diverse pathologies underlying ischemic stroke and prevention of recurrence: novel evidence on antithrombotic therapy

Q: What are the key findings of this study?

Device closure significantly reduced the annual recurrent stroke rate to 0.47% compared to 1.09% with medical therapy, with a hazard ratio of 0.41.

Q: What question did this study set out to answer?

The aim is to explore the various underlying pathologies of ischemic stroke and assess how antithrombotic therapy can help prevent recurrence.

Key Result

Device closure significantly reduced the annual recurrent stroke rate to 0.47% compared to 1.09% with medical therapy, with a hazard ratio of 0.41.

Key Points

The aim is to explore the various underlying pathologies of ischemic stroke and assess how antithrombotic therapy can help prevent recurrence.
Analyzed different pathologies associated with ischemic stroke
Reviewed antithrombotic therapy effectiveness
Examined risk factors related to stroke recurrence
Identified multiple pathologies contributing to ischemic stroke
Demonstrated that tailored antithrombotic therapies can reduce recurrence risk
Found a significant correlation between certain risk factors and stroke outcomes

Study Design

Type

Meta-Analysis

Multicenter

Yes

PICO

Population

Cryptogenic stroke (n=3,740)

Intervention / Comparator

Device closure vs Medical therapy (aspirin)

Primary Outcome

Recurrent stroke rate — HR 0.41 (0.28-0.60), p=<0.001

Abstract

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Discussion

Authors

Yuji Ueno

Journals

Nihon Naika Gakkai Zasshi

Actions

Institutions

University of Yamanashi

References and Citations

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Discussion

Cite this study

Yuji Ueno (Mon,) conducted a meta-analysis in Cryptogenic stroke (n=3,740). Device closure vs. Medical therapy (aspirin) was evaluated on Recurrent stroke rate (HR 0.41, 95% CI 0.28-0.60, p=<0.001). Device closure significantly reduced the annual recurrent stroke rate to 0.47% compared to 1.09% with medical therapy, with a hazard ratio of 0.41.

www.synapsesocial.com/papers/69b3aaa802a1e69014ccb7fc — DOI: https://doi.org/10.2169/naika.114.408

Also consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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Optimal Antithrombotic Regimens Across Atherosclerotic Vascular Beds: Toward Mechanism and Risk-Oriented Strategies· 2026 · 2 citations
When anticoagulant therapy is not enough: recurrent stroke· 2026
Repeated ischemic stroke and its prevention· 2024 · 3 citations

Diverse pathologies underlying ischemic stroke and prevention of recurrence: novel evidence on antithrombotic therapy

Key Result

Key Points

Study Design

PICO

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study

Also consider