Synergistic proanthocyanidin-copper oxygen-generating microneedle enhances anti-inflammatory activity in dental pulp stem cells and macrophage efferocytosis | Synapse
March 13, 2026Open Access
Synergistic proanthocyanidin-copper oxygen-generating microneedle enhances anti-inflammatory activity in dental pulp stem cells and macrophage efferocytosis
Key Points
The research aims to enhance the anti-inflammatory properties of human dental pulp stem cells (hDPSCs) using a novel microneedle approach.
Developed a microneedle loaded with proanthocyanidin and copper.
Tested anti-inflammatory effects on human dental pulp stem cells.
Evaluated macrophage efferocytosis in relation to the treatment.
Increased anti-inflammatory activity observed in treated hDPSCs.
Enhanced efferocytosis in macrophages was noted.
Indicates potential for improved pulp preservation strategies.
Abstract
This study represents a promising strategy for developing multifunctional biomaterials to amplify the anti-inflammatory capacity of hDPSCs and advance the field of pulp preservation and regenerative therapy.