Abstract Heart disease is the leading cause of death in the United States. Atherosclerosis, characterized by the buildup of lipids within blood vessels accompanied by the release of inflammatory cytokines and leukocyte adhesion, is a factor contributing to coronary heart disease. Another medical concern associated with elevated levels of inflammation is the rejection of implantable medical devices, such as pacemakers. In the pursuit of a natural compound that could attenuate inflammation, bovine aortic endothelial cells (BAOECs) and THP-1 cells were used. Isoquercitrin, a naturally occurring compound found in fruits and vegetables, has shown promise in mitigating inflammation and cytokine responses. To investigate the hypothesis that isoquercitrin can alleviate inflammation in BAOECs, TNF-α assays and wound healing experiments were conducted. Findings suggest that isoquercitrin does not exert significant anti-inflammatory effect on cells subjected to TNF-α-induced inflammation. Furthermore, isoquercitrin does not enhance wound healing in BAOECs. THP-1 adhesion assays were conducted with isoquercitrin to determine the impact of isoquercitrin on biocompatibility. There was no noticeable decrease in adhesion by THP-1 cells after treatment, indicating that isoquercitrin doesn’t have an impact on biomaterial rejection. Overall, isoquercitrin was not found to have anti-inflammatory effects, so it may not be suitable as an anti-inflammatory supplement.
Slee et al. (Sun,) studied this question.