Group-based trajectory modeling for declines in hepatitis B surface antigen over time accurately identifies chronic hepatitis B patients achieving functional cure: a single-center cohort study in China | Synapse
March 13, 2026Open Access
Group-based trajectory modeling for declines in hepatitis B surface antigen over time accurately identifies chronic hepatitis B patients achieving functional cure: a single-center cohort study in China
Key Points
This research aims to identify chronic hepatitis B patients likely to achieve a functional cure using group-based trajectory modeling.
Utilized group-based trajectory modeling (GBT) to categorize patients.
Focus on patients treated with PEG-IFNα.
Analyzed declines in hepatitis B surface antigen over time.
Successfully identified patients likely to achieve a functional cure.
Provided insights for personalized therapeutic strategies based on trajectory modeling.
Abstract
The GBTM-based 3-group trajectory model correctly identified PEG-IFNα-treated CHB patients likely to be "functionally cured", thereby providing a tool for devising personalized therapeutic strategies.