Plasma Phosphorylated Tau 217 and Incident Mild Cognitive Impairment and Dementia in Older Women

Key Points

• To explore the association of plasma phosphorylated tau 217 with the development of mild cognitive impairment (MCI) and dementia in older women.
• Cohort study design
• Sample included cognitively unimpaired older women
• Longitudinal assessment over 25 years
• Consideration of factors like age, race, APOE ε4, HT use
• p-tau217 is significantly associated with the development of MCI or dementia
• Findings indicate that risk factors like age and APOE ε4 influence this association
• Potential long-term predictive value of p-tau217 for cognitive decline