Plasmodium falciparum GTP-cyclohydrolase 1 (Pfgch1) Gene Copy Number Variation and Its Implications in antimalarial resistance from Northeast India

Key Points

• The aim is to explore the relationship between Pfgch1 gene copy number variations and mutations in Pfdhfr and Pfdhps that lead to antimalarial resistance.
• Analyzed gene copy number variations (CNVs) in Pfgch1
• Investigated mutations in Pfdhfr and Pfdhps genes
• Conducted statistical correlation assessments between CNVs and mutations
• Identified a positive correlation between Pfgch1 CNVs and mutations in Pfdhfr and Pfdhps
• Proposed that amplification of Pfgch1 may contribute to antifolate drug resistance in P. falciparum
• Highlighted the need for further research to confirm these relationships