Relative maternal protection against type 1 diabetes: a combined analysis of five observational studies.

Key Points

• To examine the protective effects of maternal type 1 diabetes on offspring type 1 diabetes risk, independent of genetic factors.
• Combined analysis of five observational studies
• Assessment of maternal diabetes status
• Evaluation of offspring diabetes incidence
• Analysis of genetic susceptibility using T1D-GRS2
• Intrauterine exposure to maternal type 1 diabetes was linked to reduced risk of offspring type 1 diabetes
• Protective effects appeared independent of genetic factors measured by T1D-GRS2