Transcriptome and weighted gene co-expression network analysis identify hub genes and pathways in rat kidneys after deep hypothermic circulatory arrest

Key Points

• The study aims to identify key genes and pathways affected in rat kidneys after deep hypothermic circulatory arrest (DHCA).
• Conducted transcriptome analysis on rat kidney tissues post-DHCA.
• Utilized weighted gene co-expression network analysis to discern hub genes.
• Analyzed the relationship between gene expression changes and pathological processes such as inflammation and apoptosis.
• Identified specific hub genes associated with inflammatory responses.
• Detected pathways involved in apoptosis that are altered after DHCA.
• Proposed hub genes as potential therapeutic targets for DHCA-induced acute kidney injury (AKI).