A spatiotemporally controlled MNE@PDA-Diz/GP hydrogel system: enhancing spinal cord injury repair via ROS scavenging, calcium influx inhibition, and macrophage polarization | Synapse
March 13, 2026Open Access
A spatiotemporally controlled MNE@PDA-Diz/GP hydrogel system: enhancing spinal cord injury repair via ROS scavenging, calcium influx inhibition, and macrophage polarization
Key Points
This research aims to evaluate a hydrogel system that enhances spinal cord injury repair by targeting multiple biological pathways.
Developed a photothermal-responsive hydrogel for therapy.
Integrated antioxidative and neuroprotective functions within the hydrogel.
Assessed hydrogel effects on macrophage polarization and calcium influx in spinal cord injury models.
The hydrogel improved spinal cord repair outcomes compared to traditional treatments.
Demonstrated significant reduction in reactive oxygen species (ROS).
Inhibited calcium influx and altered macrophage polarization, enhancing neuroprotection.
Abstract
A novel photothermal-responsive hydrogel enables multi-target therapy for spinal cord injury by synergistically integrating anti-oxidative, anti-inflammatory, and neuroprotective functions