What question did this study set out to answer?

To identify a gene signature associated with reactive oxygen species (ROS) in ischemic stroke (IS) and explore the role of CLEC4E.

March 13, 2026Open Access

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Systems biology analysis uncovers a ROS-associated gene signature and immunomodulatory role of CLEC4E in ischemic stroke

LYLifang YangZhejiang Provincial People's Hospital TLTing LiangZhejiang Cancer Hospital XDXiaodi DingZhejiang Provincial People's Hospital

Key Points

To identify a gene signature associated with reactive oxygen species (ROS) in ischemic stroke (IS) and explore the role of CLEC4E.
Analyzed transcriptional programs related to ROS in the context of IS.
Identified a seven-gene signature predictive of disease risk.
Investigated the role of CLEC4E in immune responses and inflammation.
A novel seven-gene signature was identified as predictive of IS risk.
CLEC4E was found to play a crucial role in connecting ROS dysregulation to immune infiltration.
Significant activation of ROS-related programs was observed in IS.

Abstract

Our study demonstrates pervasive activation of ROS-related transcriptional programs in IS and identifies a novel seven-gene signature predictive of disease risk. Among these, CLEC4E emerges as a key mediator connecting ROS dysregulation to immune infiltration and inflammatory signaling, providing new insights into IS pathophysiology and potential therapeutic targets.

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Systems biology analysis uncovers a ROS-associated gene signature and immunomodulatory role of CLEC4E in ischemic stroke

Key Points

Abstract

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