What question did this study set out to answer?

The study aims to evaluate the necessity and risks of beta-blockers in heart failure patients with preserved ejection fraction.

March 13, 20260 citations

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Are β-Blockers Necessary for Patients with Heart Failure with Preserved Ejection Fraction? : PurSuit-HFpEF Registry.

MNMasami Nishino YEYasuyuki Egami TMTaichi Mukai

Key Result

In HFpEF patients without atrial fibrillation or ischemic heart disease, β-blocker use was associated with a higher risk of mortality.

Key Points

The study aims to evaluate the necessity and risks of beta-blockers in heart failure patients with preserved ejection fraction.
Analyzed data from the PurSuit-HFpEF registry.
Focused on HFpEF patients without atrial fibrillation or ischemic heart disease.
Examined the relationship between beta-blocker use and mortality.
Beta-blocker use was linked to a higher risk of mortality in patients without AF or IHD.
Results indicate that beta-blockers may not be beneficial for all HFpEF patients.

Structured PICO

Does β-blocker use reduce mortality-related risk in HFpEF patients without AF or IHD?

Population

Patients with Heart Failure with Preserved Ejection Fraction (HFpEF) without atrial fibrillation (AF) or ischemic heart disease (IHD)

Intervention

β-blocker use

Comparator

No β-blocker use

Outcome

Mortality-related riskhard clinical

Routine β-blocker use in HFpEF patients without atrial fibrillation or ischemic heart disease is associated with increased mortality risk and should be used with caution.

Main Result

Absolute Event Rate: 0% vs 0%

Abstract

In HFpEF patients without AF or IHD, β-blocker use was associated with higher mortality-related risk, indicating that routine β-blocker use in this subgroup should be interpreted with caution.

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Cite This Study

Nishino et al. (Wed,) reported a other. In HFpEF patients without atrial fibrillation or ischemic heart disease, β-blocker use was associated with a higher risk of mortality.

synapsesocial.com/papers/69b3abf602a1e69014ccd498 https://doi.org/https://doi.org/10.1093/ejhf/xuag071

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