Common and Distinct Features in Serum Proteomic Profiles in Keratoconus, Post-Laser Vision Correction Ectasia, and Pellucid Marginal Degeneration

Key Points

• This research aims to identify shared and distinct serum proteomic profiles in keratoconus, post-laser vision correction ectasia, and pellucid marginal degeneration.
• Analyzed serum proteomic profiles from individuals with keratoconus, post-laser vision correction ectasia, and pellucid marginal degeneration.
• Examined the link between proteomic features and systemic inflammation.
• Investigated the role of eye-rubbing behavior in the development of these conditions.
• Identified common proteomic features across the ectasia conditions.
• Observed links between systemic inflammation markers and proteomic profiles.
• Suggests overlapping pathophysiological mechanisms for keratoconus and related conditions.