A bidirectional two-sample Mendelian randomization study of immune responses against Epstein-Barr virus nuclear antigen 1 and multiple sclerosis in individuals of European ancestry. | Synapse
A bidirectional two-sample Mendelian randomization study of immune responses against Epstein-Barr virus nuclear antigen 1 and multiple sclerosis in individuals of European ancestry.
The aim is to investigate the causal relationship between immune responses to EBV and multiple sclerosis risk.
Conducted a bidirectional two-sample Mendelian randomization analysis.
Analyzed genetic variants related to anti-EBNA1 IgG levels and MS risk.
Focused on individuals of European ancestry.
Found a unidirectional causal effect of elevated anti-EBNA1 IgG on MS risk.
Reinforced the involvement of EBV-related immune responses in MS pathogenesis.
Abstract
These results support a unidirectional causal effect of elevated anti-EBNA1 IgG levels on MS risk, reinforcing the role of EBV-related immune responses in MS pathogenesis.