What question did this study set out to answer?

This research aims to synthesize sulfanyl derivatives of 1,2,4-triazoles and assess their cytotoxic properties.

March 13, 2026Open Access

Synthesis of sulfanyl derivatives of 1,2,4-triazoles via an acid catalyzed intramolecular cyclization of isothiosemicarbazones: structural characterization, E / Z isomerism, mechanistic insights and in vitro cytotoxicity

Key Points

This research aims to synthesize sulfanyl derivatives of 1,2,4-triazoles and assess their cytotoxic properties.
Synthesis via Lewis or Brønsted acid catalyzed intramolecular cyclization of isothiosemicarbazones
Evaluation of the structural characteristics of the synthesized compounds
Assessment of cytotoxicity in vitro.
Sulfanyl derivatives of 1,2,4-triazoles were successfully synthesized
The evaluation revealed varying levels of cytotoxicity against cancer cells.

Abstract

Sulfanyl derivatives of 1,2,4-triazoles were synthesized via a Lewis or Brønsted acid catalyzed intramolecular cyclization of isothiosemicarbazones, and their cytotoxicity was evaluated.

Synthesis of sulfanyl derivatives of 1,2,4-triazoles via an acid catalyzed intramolecular cyclization of isothiosemicarbazones: structural characterization, E / Z isomerism, mechanistic insights and in vitro cytotoxicity

Key Points

Abstract

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