High‐sugar, high‐fat diets and physical inactivity promote the prevalence of obesity. Excess fat gradually accumulates in the liver, causing the metabolic disorder known as nonalcoholic fatty liver disease (NAFLD). As an important organ for material synthesis and output, the damage of the liver will seriously affect the health of the body, so it is of great significance to actively correct the imbalance of energy metabolism of the body. However, the pathogenesis of NAFLD has not been fully clarified due to the complexity of fat synthesis and metabolism and multiple feedback inhibition. In this study, the metabolic pathways related to lipid metabolism in NAFLD are reviewed comprehensively. Exploring the possible causes of hepatic lipid precipitation and understanding the molecular mechanism of its pathogenesis not only provides a method for drug targeted therapy but also lays a theoretical foundation for the prevention of NAFLD.
Wang et al. (Thu,) studied this question.