Optimization of Clausena anisata Leaf Extract Lozenges as Smoking Cessation Aid: Quality by Design Approach, Trial-Scale Production at Manufacturing Site, and Stability Evaluation

Key Points

• The aim is to optimize the formulation of Clausena anisata leaf extract lozenges as an aid for smoking cessation.
• Developed lozenge formulations using quality by design approach.
• Conducted trial-scale production at a manufacturing site.
• Evaluated the stability of the developed lozenges.
• Successfully optimized the lozenge formulations.
• Results indicate that the product can be scaled up for future production.
• Potential identified for use in smoking cessation initiatives.