What question did this study set out to answer?

This trial aims to assess the safety and feasibility of using sweep gas nitric oxide in ECMO circuits for neonates and children.

March 13, 2026

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Sweep Gas Nitric Oxide During Extracorporeal Membrane Oxygenation in Neonates and Children (NECTAR Trial): A Single-Center, Pilot Randomized Controlled Trial.

AMAdrian MattkeThe University of Queensland KJKerry JohnsonThe University of Queensland KGKristen GibbonsChildren's Medical Research Institute

Key Points

This trial aims to assess the safety and feasibility of using sweep gas nitric oxide in ECMO circuits for neonates and children.
Conducted as a single-center pilot randomized controlled trial
Compared sweep gas nitric oxide with standard sweep flow in ECMO circuits
Evaluated clinical outcomes related to the intervention
No significant effect of sweep gas nitric oxide on clinical outcomes was detected
The trial confirmed that the intervention is safe and feasible
Further exploration of dosage and administration routes is recommended before larger trials

Abstract

This single-center pilot RCT of sNO vs. standard sweep flow in the ECMO circuit demonstrated that such a trial is safe and feasible. However, given no effect of sNO on clinical outcomes was detected further exploration of dose and route of administration of NO should be undertaken before larger, definitive trials are conducted.

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Cite This Study

Mattke et al. (Wed,) studied this question.

synapsesocial.com/papers/69b3ac7002a1e69014cce178 https://doi.org/https://doi.org/10.1097/pcc.0000000000003926

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